Compound Monograph
Amanin
Amanin is one of the amatoxins, a group of highly poisonous cyclic peptides produced by certain deadly Amanita mushrooms.
Where Does It Come From? (1)
Amanin is a naturally occurring bicyclic peptide (amatoxin), found in Death cap and related deadly mushrooms. It is flagged as poisonous.
Research & Evidence
Amanin is a member of the amatoxin family, a group of bicyclic octapeptides produced by deadly Amanita mushrooms such as the death cap. Like the better-known alpha- and beta-amanitin, it acts by inhibiting RNA polymerase II, halting protein synthesis in cells. These are toxins, not psychedelics, and they are responsible for the lethal toxicity of the mushrooms that contain them.
Toxicity & Safety
Amatoxins are extremely poisonous. They cause severe damage to the liver and kidneys, often after a deceptive delay of many hours during which the victim feels relatively well. Poisoning by amatoxin-containing mushrooms is a medical emergency and is frequently fatal. These compounds have no safe level of ingestion.