Compound Monograph
Anhalonidine
Anhalonidine is a tetrahydroisoquinoline alkaloid found in peyote and related cacti.
Classification
Anhalonidine is a tetrahydroisoquinoline alkaloid, part of the alkaloids class. Nitrogen-containing, often bitter and physiologically potent compounds — the group behind many of the strongest plant medicines and poisons.
Where Does It Come From? (2)
Anhalonidine is a naturally occurring tetrahydroisoquinoline alkaloid, found in Peyote and 1 other source. It is flagged as moderately toxic.
Research & Evidence
Anhalonidine is one of the minor tetrahydroisoquinoline alkaloids of peyote (Lophophora williamsii), accompanying the cactus’s principal psychoactive component, mescaline. It belongs to the same chemical family as several other peyote constituents such as anhalonine and pellotine. It is not considered a major contributor to peyote’s psychedelic effects, and little is firmly established about its activity in humans on its own.
Toxicity & Safety
There is limited human safety data on isolated anhalonidine. As a minor cactus alkaloid it has not been well characterised pharmacologically or toxicologically outside its natural occurrence within peyote.