The Sunlight Experiment

Supplement Monograph

Bio PQQ

Nootropic

Pyrroloquinoline quinone — a redox cofactor studied for mitochondrial support, antioxidant activity and nerve growth factor.

Work in progress

New to nootropics? Check out this Introduction to Nootropics!

Where Does It Come From?

Bio PQQ is found naturally in humans, some fruit and veggies, and human breast milk.

Indications

  • To promote healthy ageing

Contraindications

Bio PQQ is well tolerated in short studies, but long-term human safety data are limited.

Mechanisms

  • Promotes NGF
  • Promotes mitochondrial biogenesis
  • Antioxidant
  • Coenzyme in methanol dehydrogenase and amine oxidase 3Reference 3Miyauchi K et al. · 1994Action of pyrroloquinolinequinol as an antioxidant against lipid peroxidation in solution.

Chemical Description:

Bio PQQ (pyrroloquinoline quinone) is a naturally occurring coenzyme found in human tissue and human breast milk.

Bio PQQ is a coenzyme in redox cycling. it is a reddish-brown powder, soluble in water.

Extractions/Synthesis:

PQQ is a small quinone cofactor that occurs widely in human tissue, breast milk and many plant foods, and is also produced for supplements.

Synergy:

Bio PQQ is sometimes combined with other mitochondrial-support nutrients aimed at cellular energy and antioxidant defence.

References:

  1. Salisbury SA, Forrest HS, Cruse WBT, Kennard O (1979) A novel coenzyme from bacterial primary alcohol dehydrogenase. Nature 280, 843-844.
  2. Murase K, Hattori A, Kohno M, Hayashi K (1993) Stimulation of nerve growth factor synthesis/secretion in mouse astroglial cells by coenzymes.
    Biochem Mol Biol Internat 30, 615-621.
  3. Miyauchi K, Urakami T, Abeta H, Shi H, Noguchi N, Niki E (1994) Action of pyrroloquinolinequinol as an antioxidant against lipid peroxidation in solution. Antiox Redox Signal 1, 547-554.
  4. Duine JA, Frank J, Van Zeeland JK (1979) Glucose dehydrogenase from acinetobacter calcoaceticus: a quinoprotein. FEBS letter 108, 443-446.
  5. Stites TE, Mitchel AE, Rucker RB (2000) Physiological importance of quinoenzymes and o-quinone family of cofactors. J Nutr 130, 719-727.
  6. Rucker R, Chowanadisai W, Nakano M (2009) Potential physiological importance of pyrroloquinoline quinone. Altern Med Rev 14, 268-277.
  7. Smidt CR, Steinberg FM, Rucker RB (1991) Physiological importance of pyrroloquinoline quinone. Proc Soc Exp Biol Med 197, 19-26.