Compound Monograph
Bradykinin derivatives
Bradykinin derivatives are peptides related to bradykinin, the vasoactive nine-amino-acid peptide; related forms occur in amphibian skin secretions.
Where Does It Come From? (1)
Bradykinin derivatives are naturally occurring amino acid peptides, found in Phyllomedusa frog skin secretions. They are flagged as moderately toxic.
Research & Evidence
Bradykinin is a nine-amino-acid vasoactive peptide that, in the body, dilates blood vessels, lowers blood pressure and contributes to pain and inflammation. Bradykinin-related peptides also occur in the skin secretions of various frogs, including the Phyllomedusa species used in the kambô practice, and these amphibian forms are studied as part of that secretion’s peptide makeup.
Toxicity & Safety
As vasoactive peptides, bradykinin and its relatives can cause effects such as flushing, a drop in blood pressure, swelling and pain. They are not casual substances and their presence in crude amphibian secretions is part of why such preparations carry physiological risk.