Compound Monograph
Bufotenin (5-HO-DMT)
Bufotenin is a naturally occurring psychedelic tryptamine found in toad venom, yopo snuff and other sources.
Where Does It Come From? (4)
Bufotenin (5-HO-DMT) is a naturally occurring (and made in the body) tryptamine alkaloid, found in Yopo, Toad venom, Kambo and 1 other source. It is flagged as toxic and psychedelic.
Research & Evidence
Bufotenin (5-HO-DMT) is a psychedelic tryptamine and the hydroxylated relative of DMT, structurally identical to a methylated form of serotonin. It occurs in the seeds of Anadenanthera trees used to prepare snuffs such as yopo and cohoba, in some amphibian secretions, and in trace amounts in mammals. It acts on serotonin receptors, and historical and traditional accounts describe strong psychoactive and physiological effects when these snuffs are used.
Toxicity & Safety
Bufotenin is associated with pronounced physical effects in addition to its psychoactive activity, including marked cardiovascular changes, facial flushing, nausea and a feeling of constriction, which have led some accounts to describe it as physically unpleasant or alarming. It can be toxic, particularly from animal-venom sources, and combination with MAO inhibitors or other serotonergic drugs is hazardous. It is a Schedule I substance in the United States.
Dosage
Naturalistic reports describe doses in the region of roughly 20–40 mg, though potency varies greatly with the route of administration. These figures describe doses reported in such contexts and are not a recommendation.