Compound Monograph
Cantharidin
Cantharidin is a potent blistering toxin produced by blister beetles, the active principle of the preparation known as Spanish fly.
Where Does It Come From? (2)
Cantharidin is a naturally occurring terpenoid, found in Blister beetles and Spanish fly beetle. It is flagged as poisonous.
Research & Evidence
Cantharidin is a terpenoid toxin produced by blister beetles, most famously the so-called Spanish fly (Lytta vesicatoria). It is a powerful vesicant: contact with skin or mucous membranes causes blistering, a property exploited under careful medical control to remove warts and molluscum lesions. Historically it gained a reputation as an aphrodisiac, a use that is dangerous and based on its irritant effects rather than any genuine benefit.
Toxicity & Safety
Cantharidin is highly poisonous if ingested. Swallowing even small amounts can cause severe burns to the mouth and gastrointestinal tract, kidney damage and potentially fatal poisoning, and its historical use as an aphrodisiac has caused deaths. It should only ever be encountered in properly formulated, professionally applied topical medicines, and never taken internally.