Compound Monograph
Codeine-N-oxide
Codeine-N-oxide is an N-oxide derivative of the opium alkaloid codeine.
Where Does It Come From? (1)
Codeine-N-oxide is a naturally occurring opium (morphinan) alkaloid, found in Opium poppy. It is flagged as toxic.
Opium poppy
Research & Evidence
Codeine-N-oxide is an N-oxide derivative of codeine, the well-known opium alkaloid from the poppy. It is a minor compound related to the morphinan group of opiates and has been little studied in its own right. In the United States it is listed as a Schedule I controlled substance.
Toxicity & Safety
As an opiate-related compound it should be regarded as potentially hazardous, with the dangers common to opioids, and it is a Schedule I controlled substance in the United States. Its isolated pharmacology and safety profile are not well characterised.