Compound Monograph
Deltorphins
Deltorphins are a small family of opioid peptides first isolated from the skin of South American tree frogs.
Where Does It Come From? (1)
Deltorphins are naturally occurring opioid peptide, found in Phyllomedusa tree frogs. They are flagged as moderately toxic.
Research & Evidence
Deltorphins are a group of naturally occurring opioid peptides originally found in the skin secretions of Phyllomedusa tree frogs, the same kind of source associated with the kambo preparation. They are notable in pharmacology for being unusually selective and potent agonists at the delta-opioid receptor, and they contain a D-amino acid, which is rare in animal-derived peptides. They are used mainly as research tools for studying the delta-opioid system rather than as therapeutic agents.
Toxicity & Safety
As potent opioid-receptor agonists, deltorphins are pharmacologically active peptides studied in laboratory settings rather than substances with an established human safety profile. They are not used as consumer products, and meaningful human safety data outside research are lacking.