Compound Monograph
Genistin
The glucoside of genistein, a naturally occurring storage form of the soy isoflavone in legumes.
Classification
Genistin is an isoflavone glycoside, part of the phenolics class. Antioxidant compounds built around one or more phenol rings — the flavonoids, tannins, phenolic acids, coumarins, and pigments behind much of a plant's protective chemistry.
Where Does It Come From? (4)
Genistin is a naturally occurring isoflavone glycoside, found in Soybean, Broom and 2 other sources. It is well tolerated orally (low toxicity).
Research & Evidence
Genistin is the 7-O-glucoside of genistein and one of the common storage forms in which soy isoflavones occur in legumes. After ingestion, the sugar is cleaved by gut enzymes and microbiota to release the aglycone genistein, which is the more biologically active form. It is therefore studied largely as a dietary precursor to genistein.
Toxicity & Safety
As a normal constituent of soy and related foods, genistin is considered well tolerated at dietary levels. Its hormonal activity derives mainly from the genistein released after digestion.