Compound Monograph
Harpagide
An iridoid glycoside found in wood betony and devil's claw, related to the bitter constituents of those herbs.
Classification
Harpagide is an iridoid glycoside, part of the terpenoids class. The largest class of plant compounds, built from five-carbon isoprene units — the essential-oil aromatics, resins, bitter principles, saponins, and plant sterols.
Where Does It Come From? (3)
Harpagide is a naturally occurring iridoid glycoside, found in Wood betony, Devil's claw and 1 other source. It is well tolerated orally (low toxicity).
Research & Evidence
Harpagide is an iridoid glycoside present in wood betony and in devil’s claw (Harpagophytum), from which it takes its name. It belongs to the same family of bitter iridoids as harpagoside and is studied chiefly as part of the phytochemical profile of those herbs, which are used traditionally for inflammatory and musculoskeletal complaints. Information specific to the isolated compound is limited.
Toxicity & Safety
Harpagide has not been characterised in detail for safety as an isolated compound. The herbs containing it are generally regarded as well tolerated in customary use.