Compound Monograph
Lobeline
Lobeline is the principal alkaloid of Lobelia inflata, a nicotinic-active piperidine alkaloid historically used as a respiratory stimulant and smoking aid.
Classification
Lobeline is a piperidine alkaloid, part of the alkaloids class. Nitrogen-containing, often bitter and physiologically potent compounds — the group behind many of the strongest plant medicines and poisons.
Where Does It Come From? (1)
Lobeline is a naturally occurring piperidine alkaloid, found in Lobelia. It is flagged as toxic.
Research & Evidence
Lobeline is the principal and most-studied alkaloid of Lobelia inflata (Indian tobacco), a piperidine alkaloid that interacts with nicotinic acetylcholine receptors and has complex effects on neurotransmitter systems. Historically it was used in medicine as a respiratory stimulant and emetic, and it was widely marketed in over-the-counter smoking-cessation products; the evidence that it actually helps people stop smoking is weak, and such products were eventually withdrawn from that use. It has more recently been investigated in research settings for possible effects on stimulant dependence and other conditions.
Toxicity & Safety
Lobeline and lobelia preparations are genuinely hazardous in excess. Lobelia is a powerful emetic, and overdose can cause nausea, vomiting, sweating, tremor, rapid heartbeat, hypotension and, in severe cases, more serious cardiovascular and neurological effects. It is generally contraindicated in pregnancy and in people with significant cardiac disease, and is not a substance for casual self-experimentation.