Compound Monograph
meta-Octopamine
meta-Octopamine (norfenefrine) is a trace amine and sympathomimetic phenethylamine related to noradrenaline.
Where Does It Come From?
meta-Octopamine is a naturally occurring (and made in the body) phenethylamine (trace amine). It is flagged as moderately toxic.
Research & Evidence
meta-Octopamine, better known as norfenefrine, is a phenethylamine closely related to noradrenaline, differing by the position of a hydroxyl group on the ring. It is a sympathomimetic trace amine and has been used pharmaceutically in some countries as a vasopressor to raise blood pressure. Its biological actions overlap with those of the adrenergic system.
Toxicity & Safety
As a sympathomimetic agent it can raise blood pressure and heart rate, so the relevant cautions are those for adrenergic drugs. It has not been characterised as a recreational substance.