Compound Monograph
N-Acetyldodeca-2E,4E,8Z,10E/Z-tetraenamide
An alkylamide (N-acetyl fatty-acid amide) of the type characteristic of Echinacea root.
Where Does It Come From? (1)
N-Acetyldodeca-2E,4E,8Z,10E/Z-tetraenamide is a naturally occurring fatty acid amide (n-alkylamide), found in Echinacea. It is well tolerated orally (low toxicity).
Echinacea
Research & Evidence
This is one of the alkylamides (N-alkylamides) characteristic of Echinacea species, reported as a mixture of the 10E and 10Z geometric isomers. Alkylamides are the lipophilic constituents thought to contribute to Echinacea’s tingling mouthfeel and to its proposed immune-modulating and cannabimimetic activity, with several binding cannabinoid receptors in laboratory studies. This particular minor amide has not been individually characterised in detail.