Compound Monograph
N-Isobutylamide of 2E,4E-decadienoic Acid (Pellitorine)
Pellitorine, a pungent alkylamide found in Echinacea, Anacyclus and various peppers.
Where Does It Come From? (3)
N-Isobutylamide of 2E,4E-decadienoic Acid (Pellitorine) is a naturally occurring fatty acid amide (n-alkylamide), found in Echinacea, Pellitory and Long pepper and related Piper species. It is well tolerated orally (low toxicity).
Research & Evidence
Pellitorine is the common name for the N-isobutylamide of 2E,4E-decadienoic acid, one of the most widely distributed plant alkylamides. It occurs in Echinacea, in pellitory root (Anacyclus pyrethrum) and in various peppers, and it produces a pungent, tingling, numbing sensation in the mouth. Laboratory studies have explored insecticidal, antimicrobial and other activities, but human clinical data are limited.
Toxicity & Safety
Pellitorine occurs in plants used as foods and spices and is generally encountered at low levels. Detailed human safety data for the isolated compound are limited.