Compound Monograph
N-Isobutyldodeca-2E,4E,8Z,10E/Z-tetraenamide
One of the principal alkylamides of Echinacea root.
Where Does It Come From? (1)
N-Isobutyldodeca-2E,4E,8Z,10E/Z-tetraenamide is a naturally occurring fatty acid amide (n-alkylamide), found in Echinacea. It is well tolerated orally (low toxicity).
Echinacea
Research & Evidence
This dodeca-2E,4E,8Z,10E/Z-tetraenamide is one of the major and most studied alkylamides of Echinacea root, usually present as a mixture of the 10E and 10Z isomers. It is among the constituents responsible for the characteristic tingling sensation of Echinacea preparations and is frequently used as a marker compound in quality control. Like other Echinacea alkylamides it has shown cannabinoid-receptor binding and immune-modulating activity in laboratory studies, though human clinical data remain limited.