Compound Monograph
Nicotinamide (B3)
Nicotinamide is one of the two main forms of vitamin B3 and a precursor to the essential coenzymes NAD and NADP.
Where Does It Come From? (3)
Nicotinamide is a naturally occurring (and made in the body) pyridine vitamer (vitamin b3 form), found in Meat, fish and poultry, Whole grains and Legumes and yeast. It is well tolerated orally (low toxicity).
Research & Evidence
Nicotinamide (niacinamide) is the amide form of vitamin B3 and, together with nicotinic acid, supplies the body with the building blocks for nicotinamide adenine dinucleotide (NAD+) and its phosphate (NADP+), coenzymes central to energy metabolism and hundreds of redox reactions. It is obtained from a varied diet and can also be made in the body from the amino acid tryptophan. It is used to prevent and treat vitamin B3 deficiency (pellagra) and has been studied in dermatology. Unlike nicotinic acid, nicotinamide does not cause the characteristic skin “flush.” It is a vitamin, not a stimulant or a controlled substance.
Toxicity & Safety
Nicotinamide is generally well tolerated at typical dietary and supplemental intakes. Very high doses have been associated with gastrointestinal upset and, rarely, effects on the liver, so large supplemental amounts should only be taken under medical guidance.