Compound Monograph
Noribogaine
Noribogaine is the principal active metabolite of ibogaine, the alkaloid from the iboga shrub.
Classification
Noribogaine is an indole alkaloid, part of the alkaloids class. Nitrogen-containing, often bitter and physiologically potent compounds — the group behind many of the strongest plant medicines and poisons.
Where Does It Come From? (1)
Noribogaine is a naturally occurring (and made in the body) indole alkaloid, found in Iboga. It is flagged as moderately toxic.
Research & Evidence
Noribogaine is the major long-lived metabolite formed in the body after taking ibogaine, the psychoactive alkaloid of the iboga shrub (Tabernanthe iboga). It is thought to account for much of ibogaine’s lasting activity and has a complex pharmacology, including interactions with serotonin transporters and opioid receptors. It has been investigated in the context of ibogaine’s reputed ability to interrupt opioid dependence.
Toxicity & Safety
The iboga alkaloids, including noribogaine, are associated with effects on heart rhythm — notably QT-interval prolongation — which is a serious safety concern and has been linked to fatalities during unsupervised ibogaine use. It should not be regarded as benign and is studied only under careful monitoring.