Compound Monograph
Phyllocaerulein
Phyllocaerulein is a bioactive peptide from the skin secretion of Phyllomedusa frogs, part of the Kambo complex.
Where Does It Come From? (1)
Phyllocaerulein is a naturally occurring bioactive peptide (caerulein-type), found in Kambo — skin secretion of the giant monkey frog. It is flagged as moderately toxic.
Research & Evidence
Phyllocaerulein is one of the bioactive peptides found in the skin secretion (“kambo”) of Phyllomedusa tree frogs. It belongs to the caerulein family of peptides, which act on cholecystokinin-type receptors and can stimulate secretion in the gut and gallbladder and affect blood pressure. It is thought to contribute to some of the intense, short-lived physical effects — such as nausea, vomiting and changes in blood pressure — reported during traditional kambo practice.
Toxicity & Safety
As a potent biologically active peptide, phyllocaerulein is not a casual substance. The kambo secretion that contains it can produce strong gastrointestinal and cardiovascular effects, and serious adverse events have been reported in connection with kambo rituals. It is studied as a peptide rather than used as a supplement.