Compound Monograph
Phyllokinin
Phyllokinin is a bradykinin-related peptide from the skin secretion of Phyllomedusa frogs, part of the Kambo complex.
Where Does It Come From? (1)
Phyllokinin is a naturally occurring bioactive peptide (bradykinin-related), found in Kambo — skin secretion of the giant monkey frog. It is flagged as moderately toxic.
Research & Evidence
Phyllokinin is one of the bioactive peptides found in the skin secretion (“kambo”) of Phyllomedusa tree frogs. It is a bradykinin-related peptide, and like bradykinin it can dilate blood vessels and lower blood pressure. It is considered one of the constituents responsible for the marked cardiovascular effects — such as flushing and a drop in blood pressure — that can accompany traditional kambo practice.
Toxicity & Safety
As a potent vasoactive peptide, phyllokinin is not a casual substance. The kambo secretion that contains it can cause pronounced cardiovascular and gastrointestinal reactions, and serious adverse events have been reported in connection with kambo rituals. It is studied as a peptide rather than used as a supplement.