Compound Monograph
Phyllomedusin
Phyllomedusin is a tachykinin peptide from the skin secretion of Phyllomedusa frogs, part of the Kambo complex.
Where Does It Come From? (1)
Phyllomedusin is a naturally occurring bioactive peptide (tachykinin family), found in Kambo — skin secretion of the giant monkey frog. It is flagged as moderately toxic.
Research & Evidence
Phyllomedusin is one of the bioactive peptides found in the skin secretion (“kambo”) of Phyllomedusa tree frogs. It is a tachykinin — related to substance P — and acts on smooth muscle, where it can cause powerful contraction of the gut and contribute to the intense nausea, vomiting and bowel effects characteristic of kambo. It is one of the peptides most associated with the dramatic “purge” of the practice.
Toxicity & Safety
As a potent tachykinin, phyllomedusin is not a casual substance. The kambo secretion that contains it can provoke violent gastrointestinal reactions and cardiovascular changes, and serious adverse events have been reported in connection with kambo rituals. The peptide itself is studied in pharmacology rather than used as a supplement.