Piracetam Summary:
Piracetam is the first nootropic substance ever created (by humans). It also goes by the name Nootropil and is the most popular among a series of 19 other racetam chemicals. Being a racetam means it holds the same central structure to other members of its class.
Piracetam is used to improve memory, cognitive function, and delay the onset of Alzheimer’s. It works by stimulating the release of the neurotransmitter acetylcholine.
Fortunately, this nootropic also has an incredibly high level of safety associated with its use, and is cheap to purchase all over the world. This is likely the reason behind its popularity among nootropics users.
New to nootropics? Check out this Introduction to Nootropics!
Where Does It Come From?
Piracetam is synthetic. First made in 1964, it is the prototype of the racetam class and is produced in the laboratory.
General Actions:
Piracetam modulates AMPA-type glutamate receptors, supports neuronal membrane fluidity and influences the cholinergic system, pathways involved in learning and memory.
Specific Actions:
It is reported to provide mild support for memory and overall cognition, and has been studied for neuroprotective effects.
Indications:
Piracetam is used as a general cognitive enhancer, mainly for memory and cognitive function. It is not approved as a dietary supplement in the US.
Chemical Description:
Piracetam (2-oxo-1-pyrrolidineacetamide) is a small, water-soluble molecule built around the 2-pyrrolidinone ring that defines the racetam family.
Pharmacology/Medical Research:
Piracetam is thought to act by modulating AMPA receptors, improving the fluidity of neuronal membranes and influencing cholinergic transmission. It has been studied across a range of cognitive conditions, though its precise mechanism is still not fully understood.
Toxicity:
Piracetam has a very high safety margin and is well tolerated. The most common complaint is a mild headache, which some users address by pairing it with a choline source.
Synergy:
Piracetam is frequently combined with a choline donor, which provides the building block for acetylcholine and may help reduce piracetam-related headaches.