Compound Monograph
Proscaline
Proscaline is a synthetic mescaline-analogue psychedelic of the phenethylamine class.
Where Does It Come From?
Proscaline is a naturally occurring phenethylamine (substituted mescaline analogue). It is flagged as moderately toxic and psychedelic.
Research & Evidence
Proscaline is a psychedelic phenethylamine, a structural analogue of mescaline in which the 4-position methoxy group is replaced by a propoxy group. It was among the compounds described in the research literature on mescaline analogues and acts, like other classical psychedelics, primarily through serotonin 5-HT2A receptor agonism, producing visual and cognitive effects over several hours. It is uncommon and has been little studied formally.
Toxicity & Safety
Little formal safety data exist for proscaline. As a serotonergic psychedelic it carries the general cautions of the class, including contraindication with serotonergic drugs and the potential to provoke anxiety or destabilise vulnerable individuals.
Dosage
The research literature describes an oral range of roughly 30–40 mg. These figures describe doses reported in that literature and are not a recommendation.