Supplement Monograph
Pterostilbene
A methylated, more-bioavailable cousin of resveratrol — a stilbenoid polyphenol from blueberries studied as an antioxidant.
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Where Does It Come From?
Pterostilbene is a stilbenoid found in blueberries and grapes. Structurally it is a dimethylated form of resveratrol, and the two methyl groups make it far more orally bioavailable and longer-lasting.
Specific Actions:
Pterostilbene acts as an antioxidant and is reported to activate the SIRT1 and AMPK pathways, behaving as a more bioavailable analogue of resveratrol.
Indications:
Pterostilbene has been studied for antioxidant, metabolic (blood sugar and lipids) and cognitive effects.
Chemical Description:
Pterostilbene is a stilbenoid polyphenol — a dimethylated derivative of resveratrol — which accounts for its improved oral bioavailability.
Extractions/Synthesis:
Pterostilbene occurs naturally in blueberries and grapes and is also produced for use in supplements.
Pharmacology & Medical Research
Pterostilbene’s antioxidant and neuroprotective activity has been examined in early research, much of it building on the more-studied resveratrol. (PubMed 10479711)
Pharmacodynamics:
Pterostilbene’s methyl groups slow its breakdown and improve absorption compared with resveratrol, giving it longer-lasting antioxidant activity in the body.
Synergy:
Pterostilbene is sometimes combined with other antioxidant and metabolic-support compounds.