Compound Monograph

Sauvagine

Sauvagine is a 40-amino-acid peptide from frog skin in the corticotropin-releasing factor family.

Where Does It Come From? (1)

Sauvagine is a naturally occurring peptide (corticotropin-releasing factor family), found in South American frog skin.

South American frog skin

Research & Evidence

Sauvagine is a peptide of about forty amino acids first isolated from the skin of the South American frog Phyllomedusa sauvagii. Despite being grouped here with “tachykinin”/“Kambo” tags, it belongs to the corticotropin-releasing factor (CRF) family of peptides and acts on CRF receptors, where it has been used as a research tool to study stress-hormone and cardiovascular regulation. It is studied in the laboratory rather than used as a remedy.

Toxicity & Safety

Sauvagine is a research peptide and is not used in human self-care; its safety profile outside experimental settings is not characterised.