Compound Monograph
Spilanthol
Spilanthol is the pungent alkylamide responsible for the tingling, numbing sensation of electric daisy (Acmella oleracea).
Classification
Spilanthol is an alkylamide (n-isobutylamide), part of the lipids & fatty acids class. Fats, fatty acids, and fat-soluble actives carried in seed and nut oils.
Where Does It Come From? (2)
Spilanthol is a naturally occurring alkylamide (n-isobutylamide), found in Electric daisy and 1 other source. It is well tolerated orally (low toxicity).
Research & Evidence
Spilanthol is an unsaturated isobutylamide and the main pungent principle of electric daisy (toothache plant), producing the characteristic tingling, salivating and locally numbing sensation when the flower heads are chewed. This is the basis of the plant’s traditional use for toothache and oral discomfort. It has also been examined for local anaesthetic, anti-inflammatory and insecticidal properties, mostly in laboratory studies.
Toxicity & Safety
At the levels encountered in the plant and in oral-care products, spilanthol is generally well tolerated, its most obvious effect being the transient tingling and numbness. Its safety in concentrated form has not been formally characterised.