Compound Monograph
Sulfonmethane
Sulfonmethane (sulfonal) is a sulfone-class sedative-hypnotic once widely used to induce sleep.
Where Does It Come From?
Sulfonmethane is a naturally occurring sulfone (organosulfur sedative-hypnotic). It is flagged as moderately toxic.
Research & Evidence
Sulfonmethane, better known as sulfonal, is a disulfone sedative-hypnotic introduced in the 1880s and used for insomnia before the advent of the barbiturates. Its onset is slow and its action prolonged. It is a synthetic compound rather than a natural plant constituent, despite some database listings to the contrary.
Toxicity & Safety
Sulfonal is associated with cumulative toxicity on prolonged dosing, including disturbances of porphyrin metabolism (acute porphyria-like effects), gastrointestinal upset and neurological symptoms, and it can be hazardous in overdose. It is a controlled substance (Schedule III in the United States) and is no longer used clinically.