Compound Monograph
T-kinin
T-kinin is a peptide of the bradykinin family, an N-terminally extended kinin that acts on the same vasoactive pathways.
Where Does It Come From?
T-kinin is a naturally occurring peptide (kinin / bradykinin analogue). It is flagged as moderately toxic.
Research & Evidence
T-kinin is a kinin peptide closely related to bradykinin, consisting of bradykinin extended at the N-terminus by isoleucine and serine (Ile-Ser-bradykinin). It is generated from a precursor (T-kininogen) and, like bradykinin, acts on kinin receptors to produce vasodilation, increased vascular permeability and effects on smooth muscle and pain pathways. It is a peptide rather than a tryptamine or small-molecule alkaloid, and within the context of this database it is grouped with kinin-type peptides such as those found in amphibian (kambo) secretions.
Toxicity & Safety
As a vasoactive peptide, T-kinin can provoke responses such as vasodilation, inflammation and pain when active, but it is rapidly broken down by peptidases in the body. Its safety profile outside experimental settings is not formally characterised.