Compound Monograph
Theaflavin-3,3′-digallate (TFDG)
Theaflavin-3,3′-digallate is a galloylated theaflavin from black tea, the most heavily studied member of the group.
Where Does It Come From? (1)
Theaflavin-3,3′-digallate (TFDG) is a naturally occurring theaflavin (galloylated benzotropolone polyphenol), found in Tea. It is well tolerated orally (low toxicity).
Research & Evidence
Theaflavin-3,3′-digallate (TFDG) is a theaflavin bearing two gallate groups, formed during the oxidation of tea catechins in black-tea production. Among the theaflavins it is one of the most studied in the laboratory, where it shows antioxidant activity and has been examined for various biological effects. It is a black-tea polyphenol rather than a simple flavonoid.
Toxicity & Safety
As a normal constituent of black tea, TFDG is consumed routinely and considered low in toxicity at dietary levels; isolated high-dose use has not been thoroughly characterised.