Supplement Monograph
Uridine Monophosphate
A nucleotide that supports synaptic membrane synthesis and works with choline donors for cognition.
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Where Does It Come From?
Uridine monophosphate is a pyrimidine nucleotide. It can be obtained from the diet and is also produced for use in cognitive supplements.
Specific Actions:
Uridine monophosphate raises brain phosphatidylcholine synthesis through the Kennedy pathway, supporting the formation of synaptic membranes, and has dopaminergic activity.
Indications:
- Age-related cognitive decline, especially conditions involving a loss of synaptic connection.
Chemical Description:
Uridine monophosphate is a pyrimidine nucleotide, consisting of the base uracil joined to a ribose sugar and a phosphate group.
Extractions/Synthesis:
Uridine monophosphate is obtained from dietary sources and is also manufactured for supplement use.
Pharmacology & Medical Research
Uridine monophosphate has been studied for its role in supporting synaptic membrane synthesis and cognition, particularly when combined with choline donors and DHA in the context of age-related cognitive decline.
Pharmacodynamics:
By increasing the supply of phosphatidylcholine via the Kennedy pathway, uridine monophosphate supports the building of synaptic membranes, which underlies its proposed cognitive benefits.
Synergy:
Combines well with choline donors (alpha GPC, CDP choline, etc) and DHA for cognitive support. This is due to the stimulation of free phosphatidylcholine from uridine.