Oxiracetam Summary:
Oxiracetam is a synthetic, water-soluble racetam derived from piracetam. It is used as a cognitive enhancer and is reported to support memory, focus and logical thinking, and is often described as having a mild stimulating quality.
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Where Does It Come From?
Oxiracetam is synthetic. It does not occur naturally and is produced in the laboratory as a chemical derivative of piracetam.
General Actions:
Oxiracetam modulates cholinergic and glutamatergic (AMPA/NMDA) signalling in the brain, which are pathways involved in learning and memory.
Specific Actions:
It is reported to support memory formation, focus and clarity of thought, and is sometimes used for its mild stimulating quality.
Dosage:
750 - 1600 mg
Dose is usually split up into segments 6-8 hours apart.
Indications:
Oxiracetam is used as a general cognitive enhancer, typically for memory and focus. It is not approved as a drug or dietary supplement in the US.
Chemical Description:
Water soluble. Oxiracetam shares the core 2-pyrrolidinone ring common to the racetam family.
Pharmacology/Medical Research:
Oxiracetam is thought to act through modulation of the cholinergic and glutamatergic systems, and has been studied in the context of cognitive decline. As with other racetams, the human evidence is limited and the mechanism is not fully understood.
Toxicity:
Oxiracetam is generally well tolerated at typical doses. Mild side effects such as headache may occur, which some users manage by pairing it with a choline source.
Synergy:
Oxiracetam is commonly combined with a choline donor, which supplies the raw material for acetylcholine and may help offset racetam-related headaches.