Compound Monograph
Baicalin
Baicalin is the glucuronide glycoside of baicalein and a major flavonoid of Chinese skullcap.
Classification
Baicalin is a flavonoid (flavone glucuronide), part of the phenolics class. Antioxidant compounds built around one or more phenol rings — the flavonoids, tannins, phenolic acids, coumarins, and pigments behind much of a plant's protective chemistry.
Where Does It Come From? (2)
Baicalin is a naturally occurring flavonoid (flavone glucuronide), found in Chinese skullcap and Skullcap. It is well tolerated orally (low toxicity).
Research & Evidence
Baicalin is the glucuronide glycoside of baicalein and one of the most abundant flavonoids in Chinese skullcap (Scutellaria baicalensis); in the body it can be hydrolysed to baicalein. It is frequently used as a marker compound for standardising skullcap extracts and has been studied in the laboratory for anti-inflammatory, antioxidant and calming-related activity.
Toxicity & Safety
As a flavonoid from a long-established medicinal herb, baicalin is generally regarded as low in toxicity at usual intake levels. The same general caution about possible additive effects with sedatives applies, and concentrated extracts should be distinguished from ordinary herbal use.