Compound Monograph
Beta-asarone
Beta-asarone is a phenylpropanoid from calamus and related plants, notable as a constituent of concern because of its toxic and genotoxic properties.
Classification
Beta-asarone is a phenylpropanoid, part of the phenolics class. Antioxidant compounds built around one or more phenol rings — the flavonoids, tannins, phenolic acids, coumarins, and pigments behind much of a plant's protective chemistry.
Where Does It Come From? (2)
Beta-asarone is a naturally occurring phenylpropanoid, found in Calamus / sweet flag and 1 other source. It is flagged as toxic and a known carcinogen.
Research & Evidence
Beta-asarone is the cis isomer of asarone, a phenylpropanoid found in the rhizome and essential oil of calamus (Acorus calamus) and related Acorus species. It is one of the main reasons calamus is treated with caution, since the compound accounts for much of the plant’s distinctive aroma and also its toxicity.
Toxicity & Safety
Beta-asarone is regarded as toxic and has shown genotoxic and carcinogenic activity in animal studies, leading several regulators to restrict or prohibit its use in food and to limit the asarone content of calamus preparations. High-asarone calamus and its oil are generally considered unsafe for internal use, and use during pregnancy should be avoided.