Compound Monograph
Biochanin A
Biochanin A is an isoflavone from red clover and other legumes, a methylated relative of genistein with phytoestrogenic activity.
Classification
Biochanin A is an isoflavone, part of the phenolics class. Antioxidant compounds built around one or more phenol rings — the flavonoids, tannins, phenolic acids, coumarins, and pigments behind much of a plant's protective chemistry.
Where Does It Come From? (4)
Biochanin A is a naturally occurring isoflavone, found in Red clover, Chickpea, Soy and 1 other source. It is well tolerated orally (low toxicity).
Research & Evidence
Biochanin A is an O-methylated isoflavone found in red clover, chickpeas and other legumes. In the body it can be demethylated to genistein, and like other soy and clover isoflavones it acts as a phytoestrogen, binding weakly to oestrogen receptors. It is one of the isoflavones present in red clover supplements marketed for menopausal symptoms, and it is studied in the laboratory for antioxidant and other effects.
Toxicity & Safety
As a dietary isoflavone, biochanin A is consumed at low levels in legume-based foods and is generally regarded as well tolerated. Because of its oestrogen-like activity, concentrated red clover and isoflavone supplements are often used cautiously by people with hormone-sensitive conditions, and the long-term safety of isolated high doses is not well established.