Compound Monograph
Calendulosides
Calendulosides are triterpene saponins found in calendula (pot marigold) flowers.
Classification
Calendulosides are triterpene saponins, part of the terpenoids class. The largest class of plant compounds, built from five-carbon isoprene units — the essential-oil aromatics, resins, bitter principles, saponins, and plant sterols.
Where Does It Come From? (2)
Calendulosides are naturally occurring triterpene saponins, found in Calendula / pot marigold and 1 other source. They are well tolerated orally (low toxicity).
Research & Evidence
Calendulosides are a group of triterpene saponins, mostly glycosides of oleanolic acid, found in the flowers and other parts of calendula (Calendula officinalis). They are among the characteristic constituents of this traditional wound-and-skin herb and are studied in the laboratory for anti-inflammatory and related activity, though their specific role in calendula’s traditional uses is not firmly established.
Toxicity & Safety
Calendula preparations have a long history of topical use and are generally well tolerated; as a daisy-family plant it can occasionally cause allergic reactions in sensitive individuals. The safety of isolated calendulosides has not been separately characterised.