Compound Monograph
Forskolin
Forskolin is a labdane diterpene from Indian coleus, widely used in laboratory research as a direct activator of adenylyl cyclase.
Classification
Forskolin is a diterpene (labdane), part of the terpenoids class. The largest class of plant compounds, built from five-carbon isoprene units — the essential-oil aromatics, resins, bitter principles, saponins, and plant sterols.
Where Does It Come From? (2)
Forskolin is a naturally occurring diterpene (labdane), found in Indian coleus and 1 other source. It is flagged as moderately toxic.
Research & Evidence
Forskolin is a labdane diterpene from the roots of Indian coleus (Coleus forskohlii, also classified as Plectranthus barbatus), a plant used in traditional Ayurvedic medicine. It is best known in pharmacology as a direct activator of the enzyme adenylyl cyclase, which raises intracellular cyclic AMP; this makes it an extremely common tool compound in cell biology research. It has also been marketed as a supplement for weight management and other purposes, and studied for cardiovascular and intraocular-pressure effects, but the clinical evidence is limited and inconsistent.
Toxicity & Safety
Forskolin’s strong effects on cyclic AMP signalling give it real pharmacological activity, including the potential to lower blood pressure and affect heart rate. It may interact with blood-pressure and anticoagulant medications and is generally not advised for people on such drugs or with cardiovascular conditions without medical guidance. Its safety as a long-term supplement is not well established.