Compound Monograph
Glabridin
A prenylated isoflavonoid from licorice root, studied for skin-lightening and antioxidant properties.
Classification
Glabridin is a flavonoid (prenylated isoflavan), part of the phenolics class. Antioxidant compounds built around one or more phenol rings — the flavonoids, tannins, phenolic acids, coumarins, and pigments behind much of a plant's protective chemistry.
Where Does It Come From? (1)
Glabridin is a naturally occurring flavonoid (prenylated isoflavan), found in Licorice. It is well tolerated orally (low toxicity).
Research & Evidence
Glabridin is a prenylated isoflavan and one of the characteristic flavonoids of licorice root (Glycyrrhiza glabra). It is best known as a tyrosinase inhibitor, which underlies its use in cosmetic skin-lightening preparations, and it shows antioxidant and anti-inflammatory activity in laboratory studies. It is also reported to interact with certain drug-metabolising enzymes in vitro.
Toxicity & Safety
Glabridin is a minor constituent of licorice and is generally regarded as well tolerated at the levels encountered in food and topical products. Unlike glycyrrhizin, it is not the component responsible for licorice’s effects on blood pressure and potassium. Dedicated high-dose human safety data are limited.