Compound Monograph
Nepetalactones
Nepetalactones are the iridoid monoterpene lactones of catnip responsible for its effect on cats and its insect-repellent activity.
Where Does It Come From? (2)
Nepetalactones are naturally occurring monoterpene (iridoid lactone), found in Catnip and Other Nepeta species. They are well tolerated orally (low toxicity).
Research & Evidence
Nepetalactones are iridoid monoterpene lactones and the active constituents of catnip (Nepeta cataria). They are responsible for the well-known behavioural response in many domestic cats, who react to the volatile compound with rolling, rubbing and playfulness. Nepetalactones have also attracted scientific attention as naturally occurring insect repellents, showing activity against mosquitoes and other insects in laboratory testing. Several geometric isomers occur in the plant.
Toxicity & Safety
Catnip and its nepetalactones are generally regarded as safe; the herb has a long history of use as a mild relaxing tea in humans and as a cat attractant. Detailed human toxicology for the isolated compounds is limited, but no significant hazard is associated with ordinary use.