Compound Monograph
Prenylflavonoids
Prenylflavonoids are a class of flavonoids carrying a prenyl side chain, found notably in hops.
Where Does It Come From? (1)
Prenylflavonoids are naturally occurring flavonoid (prenylated), found in Hops. They are well tolerated orally (low toxicity).
Research & Evidence
Prenylflavonoids are flavonoids that carry one or more prenyl (isoprene-derived) groups, a modification that increases their lipophilicity. They are characteristic constituents of hops, where xanthohumol and the potent phytoestrogen 8-prenylnaringenin are well-known examples, and they also occur in other plants. They are studied for antioxidant, anti-inflammatory and estrogen-related activities, though as a broad class their effects vary with the specific compound.
Toxicity & Safety
The prenylflavonoids found in hops and other dietary plants are generally regarded as low in toxicity at the levels normally consumed. Some, such as 8-prenylnaringenin, have notable estrogenic activity, which is worth bearing in mind for hormone-sensitive situations.