Compound Monograph
Wogonin
Wogonin is a methoxylated flavone characteristic of Chinese skullcap (Scutellaria baicalensis).
Classification
Wogonin is a flavonoid (methoxyflavone), part of the phenolics class. Antioxidant compounds built around one or more phenol rings — the flavonoids, tannins, phenolic acids, coumarins, and pigments behind much of a plant's protective chemistry.
Where Does It Come From? (2)
Wogonin is a naturally occurring flavonoid (methoxyflavone), found in Skullcap and Chinese skullcap. It is well tolerated orally (low toxicity).
Research & Evidence
Wogonin is an O-methylated flavone found chiefly in the roots of Chinese skullcap (Scutellaria baicalensis), alongside related flavonoids such as baicalein and baicalin. It is one of the constituents commonly cited in studies of this widely used traditional medicine. Preclinical research has examined wogonin for a range of activities including anti-inflammatory and other effects, but well-controlled human evidence for the isolated compound is limited.
Toxicity & Safety
Wogonin is found in a herb with long traditional use and is generally regarded as low in toxicity at customary intake levels. Comprehensive safety data for purified, high-dose wogonin are not established, and as with other Scutellaria preparations potential interactions are not fully characterised.