Ginger

Materia Medica

Ginger

Zingiber officinale

Ginger (Zingiber officinale) — a warming root used for nausea, vomiting, poor digestion, bloating and as an antiviral.

What Is Ginger?

Ginger is a very well known herb, mainly for its culinary applications. The warming, spicy food is useful as a medicinal as well for nausea, vomiting, menstrual irregularities, and to improve digestion and reduce bloating after meals.

Ginger is a staple herb in Chinese medicine, where it’s used in two different forms. Dried ginger is used for bleeding conditions and as a stimulant while fresh ginger serves as more of a tonic and is preferred for nausea and vomiting.

In Western herbal medicine, both fresh and dried ginger are used; however, for antiviral applications, only the fresh root or juice has been shown to provide antiviral benefits. Drying destroys the antiviral compounds, but the dried root remains effective for nausea.

Indications

  • Alcoholic gastritis
  • Bloating
  • Colic
  • Cramping
  • Diarrhea from relaxed bowel lacking inflammation
  • Drug induced nausea
  • Dysmenorrhea
  • Dyspepsia
  • Fever
  • Indigestion
  • Menstrual irregularities
  • Menstrual pain
  • Morning sickness
  • Motion sickness
  • Nausea
  • Poor digestion
  • Vomiting

Contraindications

  • None noted

What Is Ginger Used For?

Ginger is a popular culinary herb for its mild spicy flavor. Medicinally, ginger is used for its antiviral effects (fresh only), gentle stimulating action, as an anti-inflammatory, and for treating nausea and vomiting. The anti-nausea activity of ginger is robust and can be used for almost any form of nausea, including morning sickness during pregnancy, sea or car-sickness, after alcohol or drug use, stress, and gastrointestinal infection.

Ginger is also used topically for its anti-inflammatory and mildly stimulating effects best described as “warming.” Ginger salves, poultices, or tincture can be applied to the skin or sore joints to relieve the pain and down-regulate inflammation in the area through rubefacient action.

Traditional Uses

Traditional Chinese Medicine

In traditional Chinese medicine, fresh ginger and dried ginger are considered to be very different.

Dried ginger (Gan jiang) is used to warm the stomach and spleen. This action improves digestion and relieves cold conditions associated with these 2 organs. It’s often used in tonic herb formulations in order to magnify the tonic qualities of the other herbs, particularly Qi tonics 34Reference 34Teeguarden · 2000The Ancient Wisdom of the Chinese Tonic Herbs.

Dried Ginger (Gan Jiang)

Pinyin Gan jiang

Taste: Pungent (spicy) 35Reference 35Yang et al. · 2013Introduction to Chinese Materia Medica (3rd ed.), pp

Energy: Hot 35Reference 35Yang et al. · 2013Introduction to Chinese Materia Medica (3rd ed.), pp

Target organs: Spleen, kidney, lungs, and heart 34Reference 34Teeguarden · 2000The Ancient Wisdom of the Chinese Tonic Herbs.

Actions: Warms the middle jiao, rescues devastated yang, warms the lungs, relieves fluid retention, warms the channels, stops bleeding 35Reference 35Yang et al. · 2013Introduction to Chinese Materia Medica (3rd ed.), pp.

Indications: Spleen and stomach deficiency-cold patterns with gastric and abdominal cold pain, vomiting and diarrhoea 35Reference 35Yang et al. · 2013Introduction to Chinese Materia Medica (3rd ed.), pp.

Caution: Caution if using with blood heat, yin deficiency, internal heat showing a red tongue with scanty coating and dry hard stool, pregnancy. 35Reference 35Yang et al. · 2013Introduction to Chinese Materia Medica (3rd ed.), pp. Use dried ginger cautiously in pregnancy. Do not exceed 2g/day 36Reference 36Bone · 2003A Clinical Guide to Blending Liquid Herbs: Herbal Formulations for the Individual Patient.

Fresh Ginger (Sheng Jiang)

Pinyin: Sheng Jiang

Taste: Pungent 35Reference 35Yang et al. · 2013Introduction to Chinese Materia Medica (3rd ed.), pp

Energy: Warm 35Reference 35Yang et al. · 2013Introduction to Chinese Materia Medica (3rd ed.), pp

Actions: Disperses the exterior, dissipates cold, warms the center, stops vomiting, dissolves phlegm, resolves toxins, moistens and cools the interior 34,35Reference 34Teeguarden · 2000The Ancient Wisdom of the Chinese Tonic HerbsReference 35Yang et al. · 2013Introduction to Chinese Materia Medica (3rd ed.), pp.

Indications: To address dryness, and expel heat. 34Reference 34Teeguarden · 2000The Ancient Wisdom of the Chinese Tonic Herbs. Wind-cold exterior pattern, vomiting. White glossy tongue coating. 35Reference 35Yang et al. · 2013Introduction to Chinese Materia Medica (3rd ed.), pp.

Caution: Contraindicated with dry red tongue with thirst and aversion to heat 35Reference 35Yang et al. · 2013Introduction to Chinese Materia Medica (3rd ed.), pp.

Botanical Information

Ginger is a member of the Zingiberaceae family of plants which comprises 50 different genera and 1600 species of flowering plants.

The vast majority of the Zingiberaceae plants are aromatic and possess thick, creeping rhizomes. This family contains many of the most well known culinary and medicinal herbs of our time.

Some of the notable members aside from ginger includes:

  • Curcuma longa (Turmeric)
  • Alpinia galanga (Thai ginger)
  • Amomum spp. (Cardamom)
  • Hedychium spp. (Ginger lily)

Pharmacology & Research

Ginger is one of the most heavily trialled herbs in the world: PubMed indexes well over a hundred randomised controlled trials, and the strongest signals now rest on meta-analyses rather than the animal and in-vitro work that older monographs relied on. The best-supported use is exactly the traditional one — nausea, particularly the nausea and vomiting of early pregnancy, where pooled RCT data show a real effect on nausea scores 1,2,3Reference 1Viljoen E et al et al. · 2014Meta-analysisA systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting — meta-analysisView study →Reference 2Thomson M et al et al. · 2014Meta-analysisEffects of ginger for nausea and vomiting in early pregnancy: a meta-analysis — meta-analysisView study →Reference 3Matthews A et al et al. · 2015Systematic reviewInterventions for nausea and vomiting in early pregnancy — systematic review (Cochrane)View study →. Beyond emesis, replicated human trials support ginger for primary dysmenorrhea and, more modestly, osteoarthritis pain, alongside consistent anti-inflammatory and antioxidant biomarker shifts 4,5,6,9Reference 4Moshfeghinia R et al et al. · 2024Meta-analysisGinger for pain management in primary dysmenorrhea: a systematic review and meta-analysis — meta-analysisView study →Reference 5Daily JW et al et al. · 2015Meta-analysisEfficacy of ginger for alleviating the symptoms of primary dysmenorrhea: a systematic review and meta-analysis of randomized clinical trials — meta-analysisView study →Reference 6Bartels EM et al et al. · 2015Meta-analysisEfficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials — meta-analysisView study →Reference 9Rjabi S et al et al. · 2025Meta-analysisAntioxidant and anti-inflammatory effects of ginger supplementation in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomised controlled trials — meta-analysisView study →. The recurring caveat runs through almost every trial: nearly all of this evidence uses dried powdered rhizome or standardised extracts in capsules, typically 0.5–2 g/day, so it does not transfer cleanly to the 1:2 liquid extract or to fresh ginger, and preparations are rarely characterised for gingerol/shogaol content.

What the evidence supports
  • Best-supported: nausea and vomiting of pregnancy (two meta-analyses, ~1278 women) 1,2,3Reference 1Viljoen E et al et al. · 2014Meta-analysisA systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting — meta-analysisView study →Reference 2Thomson M et al et al. · 2014Meta-analysisEffects of ginger for nausea and vomiting in early pregnancy: a meta-analysis — meta-analysisView study →Reference 3Matthews A et al et al. · 2015Systematic reviewInterventions for nausea and vomiting in early pregnancy — systematic review (Cochrane)View study →, primary dysmenorrhea pain (comparable to NSAIDs) 4,5Reference 4Moshfeghinia R et al et al. · 2024Meta-analysisGinger for pain management in primary dysmenorrhea: a systematic review and meta-analysis — meta-analysisView study →Reference 5Daily JW et al et al. · 2015Meta-analysisEfficacy of ginger for alleviating the symptoms of primary dysmenorrhea: a systematic review and meta-analysis of randomized clinical trials — meta-analysisView study →, and osteoarthritis pain (modest, standardised extract) 6,7Reference 6Bartels EM et al et al. · 2015Meta-analysisEfficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials — meta-analysisView study →Reference 7Altman RD et al et al. · 2001RCTEffects of a ginger extract on knee pain in patients with osteoarthritis — randomized controlled trialView study →.
  • Emerging, worth watching: anti-inflammatory/antioxidant biomarker reductions (CRP, TNF-α, IL-6, MDA) and metabolic effects — fasting glucose, HbA1c, body weight, blood pressure — mostly from small metabolic-syndrome and T2DM trials 9,10,12,13,15Reference 9Rjabi S et al et al. · 2025Meta-analysisAntioxidant and anti-inflammatory effects of ginger supplementation in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomised controlled trials — meta-analysisView study →Reference 10Jalali M et al et al. · 2020Meta-analysisThe effects of ginger supplementation on markers of inflammatory and oxidative stress: a systematic review and meta-analysis of clinical trials — meta-analysisView study →Reference 12Ebrahimzadeh A et al et al. · 2022Meta-analysisThe effect of ginger supplementation on metabolic profiles in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials — meta-analysisView study →Reference 13Rafieipour N et al et al. · 2024Meta-analysisGinger intervention on body weight and body composition in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials — meta-analysisView study →Reference 15Hasani H et al et al. · 2019Meta-analysisDoes ginger supplementation lower blood pressure? A systematic review and meta-analysis of clinical trials — meta-analysisView study →.
  • Mechanistically thin: chemotherapy-induced nausea (meta-analysis null on incidence) 17Reference 17Choi J et al et al. · 2022Meta-analysisEffects of ginger intake on chemotherapy-induced nausea and vomiting: a systematic review of randomized clinical trials — meta-analysisView study → and motion sickness (trial evidence contradictory despite strong traditional use) 24Reference 24Stewart JJ et al et al. · 1991RCTEffects of ginger on motion sickness susceptibility and gastric function — randomized controlled trialView study →.
  • The caveat: the evidence base is powder/standardised-extract, not the liquid extract or fresh root the monograph centres on; heterogeneity is high and few trials report the actual gingerol dose delivered 26,30Reference 26Nikkhah Bodagh M et al et al. · 2019Systematic reviewGinger in gastrointestinal disorders: a systematic review of clinical trials — systematic reviewView study →Reference 30Anh NH et al et al. · 2020Systematic reviewGinger on human health: a comprehensive systematic review of 109 randomized controlled trials — systematic reviewView study →.
0. Evidence by indication

Support is an experimental score I’m building — a composite weighted by study type (human > animal > in vitro > review) and study volume. It’s a beta: a fast way to rank strength of evidence at a glance, not a validated metric, and I’ll keep honing the formula over time. Each indication name links down to its write-up.

IndicationSupportRests on
Nausea and vomiting of pregnancy████████░░ 82%Two meta-analyses (12 RCTs, n≈1278) — significant nausea relief vs placebo; low-dose powder/capsule, the form actually studied 1,2,3Reference 1Viljoen E et al et al. · 2014Meta-analysisA systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting — meta-analysisView study →Reference 2Thomson M et al et al. · 2014Meta-analysisEffects of ginger for nausea and vomiting in early pregnancy: a meta-analysis — meta-analysisView study →Reference 3Matthews A et al et al. · 2015Systematic reviewInterventions for nausea and vomiting in early pregnancy — systematic review (Cochrane)View study →.
Primary dysmenorrhea████████░░ 76%Two meta-analyses — large pain-intensity reduction vs placebo, comparable to NSAIDs; powder 750–2000 mg/day over early menses 4,5Reference 4Moshfeghinia R et al et al. · 2024Meta-analysisGinger for pain management in primary dysmenorrhea: a systematic review and meta-analysis — meta-analysisView study →Reference 5Daily JW et al et al. · 2015Meta-analysisEfficacy of ginger for alleviating the symptoms of primary dysmenorrhea: a systematic review and meta-analysis of randomized clinical trials — meta-analysisView study →.
Osteoarthritis███████░░░ 70%Meta-analysis + landmark n=247 RCT — modest but significant pain reduction with standardised extract; GI dropout roughly doubled 6,7,8Reference 6Bartels EM et al et al. · 2015Meta-analysisEfficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials — meta-analysisView study →Reference 7Altman RD et al et al. · 2001RCTEffects of a ginger extract on knee pain in patients with osteoarthritis — randomized controlled trialView study →Reference 8Araya-Quintanilla F et al et al. · 2020Meta-analysisEffectiveness of ginger on pain and function in knee osteoarthritis: a PRISMA systematic review and meta-analysis — meta-analysisView study →.
Anti-inflammatory and antioxidant activity███████░░░ 68%RCT meta-analyses — consistent CRP, TNF-α, IL-6 and MDA reductions; surrogate biomarkers, not clinical endpoints 9,10,11Reference 9Rjabi S et al et al. · 2025Meta-analysisAntioxidant and anti-inflammatory effects of ginger supplementation in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomised controlled trials — meta-analysisView study →Reference 10Jalali M et al et al. · 2020Meta-analysisThe effects of ginger supplementation on markers of inflammatory and oxidative stress: a systematic review and meta-analysis of clinical trials — meta-analysisView study →Reference 11Sheikhhossein F et al et al. · 2021Meta-analysisEffects of ginger supplementation on biomarkers of oxidative stress: a systematic review and meta-analysis of randomized controlled trials — meta-analysisView study →.
Postoperative nausea and vomiting███████░░░ 66%One meta-analysis — lower 6-hour nausea incidence and rescue-antiemetic use vs placebo; capsule/powder pre-operatively 20Reference 20Zhu W et al et al. · 2021Meta-analysisEfficacy of ginger in preventing postoperative nausea and vomiting: a systematic review and meta-analysis — meta-analysisView study →.
Glycemic control in type 2 diabetes██████░░░░ 64%Meta-analysis in T2DM — significant fasting glucose and HbA1c reductions, but high heterogeneity; 1600–3000 mg/day powder 12Reference 12Ebrahimzadeh A et al et al. · 2022Meta-analysisThe effect of ginger supplementation on metabolic profiles in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials — meta-analysisView study →.
Body weight and metabolic markers██████░░░░ 60%Two meta-analyses — small significant drops in body weight, BMI and waist circumference; effect appears above ~2 g/day over ≥8 weeks 13,14Reference 13Rafieipour N et al et al. · 2024Meta-analysisGinger intervention on body weight and body composition in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials — meta-analysisView study →Reference 14Maharlouei N et al et al. · 2019Meta-analysisThe effects of ginger intake on weight loss and metabolic profiles among overweight and obese subjects: a systematic review and meta-analysis of randomized controlled trials — meta-analysisView study →.
Blood pressure██████░░░░ 56%Meta-analysis — significant SBP/DBP reduction, but only in younger participants and short trials, with high heterogeneity 15Reference 15Hasani H et al et al. · 2019Meta-analysisDoes ginger supplementation lower blood pressure? A systematic review and meta-analysis of clinical trials — meta-analysisView study →.
Migraine█████░░░░░ 52%Small RCTs — acute relief comparable to sumatriptan and as add-on, but a prophylaxis trial was null; powder 250 mg–1.5 g 21,22,23Reference 21Maghbooli M et al et al. · 2014RCTComparison between the efficacy of ginger and sumatriptan in the ablative treatment of the common migraine — randomized controlled trialView study →Reference 22Martins LB et al et al. · 2019RCTDouble-blind placebo-controlled randomized clinical trial of ginger (Zingiber officinale Rosc.) addition in migraine acute treatment — randomized controlled trialView study →Reference 23Martins LB et al et al. · 2020RCTDouble-blind placebo-controlled randomized clinical trial of ginger (Zingiber officinale Rosc.) in the prophylactic treatment of migraine — randomized controlled trialView study →.
Serum lipids█████░░░░░ 46%Meta-analyses disagree — modest TC/TG reductions in one, no lipid effect in T2DM- and obesity-specific pooled analyses 16,12,14Reference 16Salih AK et al et al. · 2023Meta-analysisEffect of ginger (Zingiber officinale) intake on human serum lipid profile: systematic review and meta-analysis — meta-analysisView study →Reference 12Ebrahimzadeh A et al et al. · 2022Meta-analysisThe effect of ginger supplementation on metabolic profiles in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials — meta-analysisView study →Reference 14Maharlouei N et al et al. · 2019Meta-analysisThe effects of ginger intake on weight loss and metabolic profiles among overweight and obese subjects: a systematic review and meta-analysis of randomized controlled trials — meta-analysisView study →.
Chemotherapy-induced nausea and vomiting████░░░░░░ 44%Meta-analysis null on acute/delayed incidence; a 2024 RCT improved nausea-related quality of life but not acute CINV 17,18,19Reference 17Choi J et al et al. · 2022Meta-analysisEffects of ginger intake on chemotherapy-induced nausea and vomiting: a systematic review of randomized clinical trials — meta-analysisView study →Reference 18Crichton M et al et al. · 2024RCTEffect of a standardized ginger root powder regimen on chemotherapy-induced nausea and vomiting: a multicenter, double-blind, placebo-controlled randomized trial — randomized controlled trialView study →Reference 19Marx W et al et al. · 2017ReviewGinger — mechanism of action in chemotherapy-induced nausea and vomiting: a review — reviewView study →.
Motion sickness████░░░░░░ 38%Traditional use is strong but trials are contradictory; a controlled study found no effect on susceptibility or gastric function 24Reference 24Stewart JJ et al et al. · 1991RCTEffects of ginger on motion sickness susceptibility and gastric function — randomized controlled trialView study →.
1. Nausea and vomiting of pregnancy

This is ginger’s best-evidenced use and it aligns with centuries of traditional practice. A meta-analysis of 12 RCTs (n≈1278) found ginger significantly improved nausea versus placebo (mean difference 1.20 on nausea scales, 95% CI 0.56–1.84), though the reduction in actual vomiting episodes only trended toward significance (MD 0.72, 95% CI −0.03–1.46) 1Reference 1Viljoen E et al et al. · 2014Meta-analysisA systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting — meta-analysisView study →. A second meta-analysis reached the same conclusion — ginger relieved nausea more than placebo and was comparable to vitamin B6, with no increase in miscarriage or adverse pregnancy outcomes 2Reference 2Thomson M et al et al. · 2014Meta-analysisEffects of ginger for nausea and vomiting in early pregnancy: a meta-analysis — meta-analysisView study →. The Cochrane review of interventions for early-pregnancy nausea rates the ginger evidence as limited and inconsistent in quality but broadly supportive 3Reference 3Matthews A et al et al. · 2015Systematic reviewInterventions for nausea and vomiting in early pregnancy — systematic review (Cochrane)View study →. Subgroup analysis favoured lower daily doses (<1500 mg of powdered rhizome), the divided-dose form used in practice 1,26Reference 1Viljoen E et al et al. · 2014Meta-analysisA systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting — meta-analysisView study →Reference 26Nikkhah Bodagh M et al et al. · 2019Systematic reviewGinger in gastrointestinal disorders: a systematic review of clinical trials — systematic reviewView study →.

Gap: trials use powdered/capsule ginger, not the 1:2 liquid extract; the effect on vomiting (as opposed to nausea) is weaker, and long-term fetal-safety data remain thin.

2. Primary dysmenorrhea

Two meta-analyses support ginger for menstrual pain. A 2024 review found ginger notably more effective than placebo at reducing both pain intensity (shogaol- and gingerol-standardised powder; SMD −1.13, 95% CI −1.59 to −0.68) and pain duration, and — importantly — found no significant difference between ginger and NSAIDs for pain intensity (SMD 0.01, 95% CI −0.24 to 0.25) 4Reference 4Moshfeghinia R et al et al. · 2024Meta-analysisGinger for pain management in primary dysmenorrhea: a systematic review and meta-analysis — meta-analysisView study →. An earlier meta-analysis reported a similarly large reduction in the pain visual-analogue score versus placebo 5Reference 5Daily JW et al et al. · 2015Meta-analysisEfficacy of ginger for alleviating the symptoms of primary dysmenorrhea: a systematic review and meta-analysis of randomized clinical trials — meta-analysisView study →. Effective regimens clustered around 750–2000 mg/day of powder taken over the first three to four days of menses 4Reference 4Moshfeghinia R et al et al. · 2024Meta-analysisGinger for pain management in primary dysmenorrhea: a systematic review and meta-analysis — meta-analysisView study →.

Gap: trials are small and mostly conducted in student populations; head-to-head equivalence with NSAIDs rests on modest numbers, and the liquid-extract form used on this page is untested here.

3. Osteoarthritis

A meta-analysis of placebo-controlled RCTs found a statistically significant but modest reduction in OA pain (SMD −0.30, 95% CI −0.50 to −0.09) and disability, with low heterogeneity — but patients on ginger were more than twice as likely to stop treatment because of (mostly gastrointestinal) side effects (RR 2.33, 95% CI 1.04–5.22) 6Reference 6Bartels EM et al et al. · 2015Meta-analysisEfficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials — meta-analysisView study →. The landmark trial behind this signal randomised 247 knee-OA patients to a highly purified, standardised ginger extract and found a superior responder rate versus placebo (63% vs 50%, P = 0.048) 7Reference 7Altman RD et al et al. · 2001RCTEffects of a ginger extract on knee pain in patients with osteoarthritis — randomized controlled trialView study →. A later systematic review found oral capsules beat placebo for pain but topical ginger did not clearly outperform standard care 8Reference 8Araya-Quintanilla F et al et al. · 2020Meta-analysisEffectiveness of ginger on pain and function in knee osteoarthritis: a PRISMA systematic review and meta-analysis — meta-analysisView study →.

Gap: benefit is real but small, works only for the standardised extract (not tea or crude powder), and comes with a meaningful GI-tolerability cost that caps its practical value.

4. Anti-inflammatory and antioxidant activity

This is the mechanistic engine beneath ginger’s pain and metabolic effects, and it is now supported by human biomarker data rather than cell lines alone. A 2025 GRADE-assessed dose-response meta-analysis found ginger supplementation reduced C-reactive protein (WMD −0.86 mg/L), TNF-α (−1.90 pg/mL) and IL-6 (−1.15 pg/mL) while improving antioxidant capacity 9Reference 9Rjabi S et al et al. · 2025Meta-analysisAntioxidant and anti-inflammatory effects of ginger supplementation in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomised controlled trials — meta-analysisView study →. Two earlier meta-analyses concur, reporting significant drops in CRP, TNF-α, IL-6 and the oxidative-stress marker malondialdehyde (gingerol and shogaol inhibit NF-κB and COX-2/prostaglandin signalling), with a marginal effect on PGE2 10,11Reference 10Jalali M et al et al. · 2020Meta-analysisThe effects of ginger supplementation on markers of inflammatory and oxidative stress: a systematic review and meta-analysis of clinical trials — meta-analysisView study →Reference 11Sheikhhossein F et al et al. · 2021Meta-analysisEffects of ginger supplementation on biomarkers of oxidative stress: a systematic review and meta-analysis of randomized controlled trials — meta-analysisView study →. Larger MDA reductions appeared at doses ≤1 g/day over shorter courses 11Reference 11Sheikhhossein F et al et al. · 2021Meta-analysisEffects of ginger supplementation on biomarkers of oxidative stress: a systematic review and meta-analysis of randomized controlled trials — meta-analysisView study →.

Gap: these are surrogate biomarkers, not clinical outcomes — a lower CRP is not itself a treated disease, and heterogeneity across trials is high.

5. Postoperative nausea and vomiting

A meta-analysis of perioperative RCTs found that, versus placebo, ginger lowered nausea severity (MD −0.71), reduced the incidence of nausea and vomiting in the first six hours after surgery (RR 0.68), and cut rescue-antiemetic use (RR 0.71) 20Reference 20Zhu W et al et al. · 2021Meta-analysisEfficacy of ginger in preventing postoperative nausea and vomiting: a systematic review and meta-analysis — meta-analysisView study →. Against active prophylactic antiemetics ginger was slightly better for nausea incidence but no different for vomiting, positioning it as an adjunct rather than a replacement 20Reference 20Zhu W et al et al. · 2021Meta-analysisEfficacy of ginger in preventing postoperative nausea and vomiting: a systematic review and meta-analysis — meta-analysisView study →. Regimens were capsule or powder given pre-operatively, consistent with the anti-emetic mechanism ginger shares across nausea types.

Gap: trials are heterogeneous in surgery type and dosing schedule, and ginger’s antiplatelet activity raises a theoretical perioperative bleeding concern that these efficacy trials were not designed to detect (see Safety).

6. Glycemic control in type 2 diabetes

A meta-analysis of RCTs in people with type 2 diabetes found ginger supplementation significantly reduced fasting blood sugar (WMD −18.81 mg/dL, 95% CI −28.70 to −8.92) and HbA1c (WMD −0.57%), alongside small blood-pressure reductions, at doses of roughly 1600–3000 mg/day of powder 12Reference 12Ebrahimzadeh A et al et al. · 2022Meta-analysisThe effect of ginger supplementation on metabolic profiles in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials — meta-analysisView study →. The direction is consistent with ginger’s insulin-sensitising and anti-inflammatory mechanisms, but between-study heterogeneity was high (I² ≈ 77%) and trials were short. Lipid outcomes in the same diabetic populations were not significantly changed 12Reference 12Ebrahimzadeh A et al et al. · 2022Meta-analysisThe effect of ginger supplementation on metabolic profiles in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials — meta-analysisView study →.

Gap: heterogeneity is substantial, trials are brief, and no data address hard diabetic endpoints or interaction with glucose-lowering drugs — a plausible additive-hypoglycaemia concern.

7. Body weight and metabolic markers

Two meta-analyses find small but consistent anthropometric effects. A 2024 GRADE-assessed dose-response review of 27 RCTs reported reductions in body weight (WMD −1.52 kg), BMI (−0.58 kg/m²) and waist circumference (−1.04 cm), with a non-linear effect emerging around 2 g/day over more than eight weeks 13Reference 13Rafieipour N et al et al. · 2024Meta-analysisGinger intervention on body weight and body composition in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials — meta-analysisView study →. An earlier meta-analysis in overweight and obese subjects found ginger lowered body weight, waist-to-hip ratio, fasting glucose and HOMA-IR and raised HDL, without affecting BMI, insulin or triglycerides 14Reference 14Maharlouei N et al et al. · 2019Meta-analysisThe effects of ginger intake on weight loss and metabolic profiles among overweight and obese subjects: a systematic review and meta-analysis of randomized controlled trials — meta-analysisView study →.

Gap: effect sizes are clinically small (roughly 1–1.5 kg), driven by short trials in metabolic-syndrome populations, and confounded by variable diet and exercise co-interventions.

8. Blood pressure

A meta-analysis of six RCTs (n=345) found ginger supplementation lowered systolic (MD −6.36 mmHg, 95% CI −11.27 to −1.46) and diastolic (MD −2.12 mmHg) blood pressure 15Reference 15Hasani H et al et al. · 2019Meta-analysisDoes ginger supplementation lower blood pressure? A systematic review and meta-analysis of clinical trials — meta-analysisView study →. The effect was concentrated in participants under 50 and in trials of eight weeks or less, and heterogeneity was very high (I² ≈ 90%), so the pooled figure likely overstates a real but variable effect 15Reference 15Hasani H et al et al. · 2019Meta-analysisDoes ginger supplementation lower blood pressure? A systematic review and meta-analysis of clinical trials — meta-analysisView study →. Consistent with the vasodilatory and antioxidant mechanisms, higher doses tended to produce larger reductions.

Gap: few trials, extreme heterogeneity, and effects limited to younger, shorter-duration studies — not yet a basis for treating hypertension.

9. Migraine

Small RCTs are encouraging for acute attacks but not for prevention. A double-blind trial of 100 patients found 250 mg ginger powder comparable to sumatriptan for aborting a common migraine attack, with fewer side effects 21Reference 21Maghbooli M et al et al. · 2014RCTComparison between the efficacy of ginger and sumatriptan in the ablative treatment of the common migraine — randomized controlled trialView study →. A second RCT found ginger, added to standard emergency-room treatment, improved clinical response at 1–2 hours versus placebo 22Reference 22Martins LB et al et al. · 2019RCTDouble-blind placebo-controlled randomized clinical trial of ginger (Zingiber officinale Rosc.) addition in migraine acute treatment — randomized controlled trialView study →. But a prophylaxis trial from the same group found no difference from placebo in the proportion of patients achieving a 50% reduction in attack frequency 23Reference 23Martins LB et al et al. · 2020RCTDouble-blind placebo-controlled randomized clinical trial of ginger (Zingiber officinale Rosc.) in the prophylactic treatment of migraine — randomized controlled trialView study →.

Gap: acute-treatment trials are small and single-centre; the one prophylaxis RCT was null, so ginger’s role appears limited to symptomatic relief, not prevention.

10. Serum lipids

The lipid evidence is genuinely mixed and preparation- and population-dependent. A 2023 meta-analysis found ginger significantly reduced total cholesterol (SMD −0.44) and triglycerides (SMD −0.61), with a dose-dependent effect on total cholesterol 16Reference 16Salih AK et al et al. · 2023Meta-analysisEffect of ginger (Zingiber officinale) intake on human serum lipid profile: systematic review and meta-analysis — meta-analysisView study →. But the T2DM-specific meta-analysis found no significant change in TG, TC, LDL or HDL 12Reference 12Ebrahimzadeh A et al et al. · 2022Meta-analysisThe effect of ginger supplementation on metabolic profiles in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials — meta-analysisView study →, and the overweight/obese meta-analysis likewise found no triglyceride or LDL effect 14Reference 14Maharlouei N et al et al. · 2019Meta-analysisThe effects of ginger intake on weight loss and metabolic profiles among overweight and obese subjects: a systematic review and meta-analysis of randomized controlled trials — meta-analysisView study →. The signal, where present, is small and inconsistent across populations.

Gap: meta-analyses contradict each other by population and preparation; ginger is not a reliable lipid-lowering agent on current data.

11. Chemotherapy-induced nausea and vomiting

Despite a strong mechanistic rationale, the clinical picture here is disappointing. A systematic review and meta-analysis of 23 RCTs found ginger did not significantly reduce the incidence of acute nausea (P = 0.53), delayed nausea (P = 0.31), acute vomiting (P = 0.09) or delayed vomiting (P = 0.89) 17Reference 17Choi J et al et al. · 2022Meta-analysisEffects of ginger intake on chemotherapy-induced nausea and vomiting: a systematic review of randomized clinical trials — meta-analysisView study →. A 2024 multicentre double-blind RCT of standardised ginger root powder found it improved nausea-related quality of life and overall CINV-related quality of life, but had no effect on anticipatory or acute CINV itself 18Reference 18Crichton M et al et al. · 2024RCTEffect of a standardized ginger root powder regimen on chemotherapy-induced nausea and vomiting: a multicenter, double-blind, placebo-controlled randomized trial — randomized controlled trialView study →. Mechanistically, ginger’s gingerol and shogaol constituents act as 5-HT3 receptor negative allosteric modulators and NK-1 antagonists — the same targets as standard antiemetics — which is why the null incidence data are surprising 19,25Reference 19Marx W et al et al. · 2017ReviewGinger — mechanism of action in chemotherapy-induced nausea and vomiting: a review — reviewView study →Reference 25Al Kury LT et al et al. · 2018ReviewNatural negative allosteric modulators of 5-HT3 receptors — reviewView study →.

Gap: the mechanism predicts benefit that the pooled incidence data do not confirm; any real effect seems confined to quality-of-life measures, and trials vary widely in chemotherapy regimen and background antiemetics.

12. Motion sickness

Traditional use for travel sickness is long-standing, but controlled evidence is contradictory. A controlled crossover study found ginger had no effect on motion-sickness susceptibility during circular-vection testing and did not alter gastric function, directly challenging the popular claim 24Reference 24Stewart JJ et al et al. · 1991RCTEffects of ginger on motion sickness susceptibility and gastric function — randomized controlled trialView study →. Other early trials reported benefit, but the body of evidence does not converge, and the effect — if present — may depend on the provocation model used.

Gap: the best-controlled study is null; the indication rests more on tradition and a plausible gastric-motility mechanism than on consistent trial data.

Mechanisms

MechanismDrivesKey compounds
5-HT3 receptor negative allosteric modulation, NK-1 antagonism, enhanced gastric emptyinganti-nausea (pregnancy, PONV), pro-kinetic digestiongingerol, shogaol
NF-κB ↓, COX-2 ↓, prostaglandin/PGE₂ and leukotriene inhibitionanti-inflammatory, dysmenorrhea, osteoarthritisgingerol, shogaol
↑ glutathione peroxidase & total antioxidant capacity, ↓ malondialdehydeantioxidant, metabolic/vascular protectiongingerol, zingerone
Thromboxane synthesis ↓, platelet aggregation ↓antiplatelet (also a bleeding-interaction risk)gingerol
Carminative, spasmolytic, warming/rubefacient (topical)carminative, topical anti-inflammatoryzingiberene, paradol

Clinical trials

Ginger is exceptional among herbs for its trial volume — a 2020 systematic review catalogued 109 randomised controlled trials in humans, and dozens of meta-analyses now pool them by indication 30,31Reference 30Anh NH et al et al. · 2020Systematic reviewGinger on human health: a comprehensive systematic review of 109 randomized controlled trials — systematic reviewView study →Reference 31Paudel KR et al et al. · 2025Meta-analysisPharmacological properties of ginger (Zingiber officinale): what do meta-analyses say? A systematic review — systematic reviewView study →. The counts below are approximate and cover the indications reviewed here, not every registered ginger study.

CompletedPlannedTerminatedPreclinical
~100+ RCTs (20 meta-analyses reviewed here)Hundreds

Last checked: June 2026.

Phytochemistry

Ginger’s warmth and medicine come from two sets of compounds. The pungent principles are the gingerols — 6-gingerol most of all — which dominate the fresh rhizome and carry much of its anti-inflammatory, anti-nausea and digestive-stimulating activity 32,33Reference 32Baliga MS et al et al. · 2011ReviewUpdate on the chemopreventive effects of ginger and its phytochemicals — reviewReference 33Chrubasik S et al. · 2005ReviewZingiberis rhizoma: a comprehensive review on the ginger effect and efficacy profiles — review. When the root is dried or heated these dehydrate into the sharper, more pungent shogaols, and with further cooking into milder zingerone; this shift is why traditional Chinese medicine treats fresh (Sheng Jiang) and dried (Gan Jiang) ginger as distinct remedies 32,33Reference 32Baliga MS et al et al. · 2011ReviewUpdate on the chemopreventive effects of ginger and its phytochemicals — reviewReference 33Chrubasik S et al. · 2005ReviewZingiberis rhizoma: a comprehensive review on the ginger effect and efficacy profiles — review. The second set is the aromatic essential oil (~1–3% of the rhizome), built largely on the sesquiterpene zingiberene alongside paradol and other volatiles 33Reference 33Chrubasik S et al. · 2005ReviewZingiberis rhizoma: a comprehensive review on the ginger effect and efficacy profiles — review.

Constituent Summary

Amounts vary widely with cultivar, freshness and preparation; gingerols convert to shogaols as the rhizome is dried 32,33Reference 32Baliga MS et al et al. · 2011ReviewUpdate on the chemopreventive effects of ginger and its phytochemicals — reviewReference 33Chrubasik S et al. · 2005ReviewZingiberis rhizoma: a comprehensive review on the ginger effect and efficacy profiles — review.

Grouped by class · 5 compounds
Phenylpropanoid4 compounds3 with data
PhenylpropanoidGingerolsmajor pungent principle (fresh)
PhenylpropanoidShogaolslow in fresh, rises on drying
PhenylpropanoidZingeroneforms on cooking
PhenylpropanoidParadolNo data
Sesquiterpene1 compound1 with data
SesquiterpeneZingiberenemajor in essential oil

Clinical Applications

Ginger is useful as an antiviral if the fresh juice is used and at the first sign of infection. The anti-nausea effects of ginger are among its most reliable activities, working across a wide range of unrelated causes.

Ginger is also useful for treating flatulence, or bloating after meals, and can improve the digestive process by stimulating the release of digestive enzymes.

Topically, ginger is a reliable rubefacient useful for treating rheumatoid arthritis and muscle aches.

Dosage

In research, ginger is almost always given as dried powdered rhizome or a standardised capsule extract, typically 0.5–2 g/day in divided doses — not the fresh root or the 1:2 liquid extract this page’s sidebar lists. Here’s a roundup of the doses used:

IndicationPreparationDoseEst. dried-herb equivalentSource
Nausea & vomiting of pregnancyDried powdered rhizome (capsules), divided<1.5 g/day~1–1.5 g dried rhizome1,2,3Reference 1Viljoen E et al et al. · 2014Meta-analysisA systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting — meta-analysisView study →Reference 2Thomson M et al et al. · 2014Meta-analysisEffects of ginger for nausea and vomiting in early pregnancy: a meta-analysis — meta-analysisView study →Reference 3Matthews A et al et al. · 2015Systematic reviewInterventions for nausea and vomiting in early pregnancy — systematic review (Cochrane)View study →
Primary dysmenorrheaDried powdered rhizome750–2,000 mg/day over the first 3–4 days of mensesas dosed4,5Reference 4Moshfeghinia R et al et al. · 2024Meta-analysisGinger for pain management in primary dysmenorrhea: a systematic review and meta-analysis — meta-analysisView study →Reference 5Daily JW et al et al. · 2015Meta-analysisEfficacy of ginger for alleviating the symptoms of primary dysmenorrhea: a systematic review and meta-analysis of randomized clinical trials — meta-analysisView study →
OsteoarthritisHighly purified standardised extracttwice daily(extract-based)6,7Reference 6Bartels EM et al et al. · 2015Meta-analysisEfficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials — meta-analysisView study →Reference 7Altman RD et al et al. · 2001RCTEffects of a ginger extract on knee pain in patients with osteoarthritis — randomized controlled trialView study →
Glycemic control (type 2 diabetes)Dried powdered rhizome1,600–3,000 mg/dayas dosed12Reference 12Ebrahimzadeh A et al et al. · 2022Meta-analysisThe effect of ginger supplementation on metabolic profiles in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials — meta-analysisView study →
Body weight / metabolic markersDried powdered rhizome~2 g/day for ≥8 weeksas dosed13,14Reference 13Rafieipour N et al et al. · 2024Meta-analysisGinger intervention on body weight and body composition in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials — meta-analysisView study →Reference 14Maharlouei N et al et al. · 2019Meta-analysisThe effects of ginger intake on weight loss and metabolic profiles among overweight and obese subjects: a systematic review and meta-analysis of randomized controlled trials — meta-analysisView study →
Migraine (acute attack)Dried powdered rhizome250 mg–1.5 g per attackas dosed21,22Reference 21Maghbooli M et al et al. · 2014RCTComparison between the efficacy of ginger and sumatriptan in the ablative treatment of the common migraine — randomized controlled trialView study →Reference 22Martins LB et al et al. · 2019RCTDouble-blind placebo-controlled randomized clinical trial of ginger (Zingiber officinale Rosc.) addition in migraine acute treatment — randomized controlled trialView study →

Because powdered rhizome is simply dried ginger, the “dried-herb equivalent” for those rows is the dose itself; the osteoarthritis row uses a purified standardised extract, so no reliable whole-herb equivalent can be given (marked extract-based). These are guides, not recommendations, and the evidence is for powder/extract, not the fresh root or 1:2 liquid extract.

Traditional Dosage

In Western herbal medicine and Traditional Chinese Medicine, ginger is used as the whole fresh or dried root, a tincture, or a liquid extract — with fresh (Sheng Jiang) and dried (Gan Jiang) ginger treated as distinct remedies.

SystemPreparationDose
Western herbal1:2 liquid extract5–15 mL
Western herbalFresh rhizome (tea / culinary)1–3 g
TCM — Sheng Jiang (fresh ginger)Sliced decoction3–9 g 35Reference 35Yang et al. · 2013Introduction to Chinese Materia Medica (3rd ed.), pp
TCM — Gan Jiang (dried ginger)Decoction≤2 g/day 36Reference 36Bone · 2003A Clinical Guide to Blending Liquid Herbs: Herbal Formulations for the Individual Patient

Safety

Ginger is well tolerated: adverse effects in trials are mostly mild and gastrointestinal — heartburn, belching and stomach discomfort — and in osteoarthritis trials this was enough to roughly double the treatment-discontinuation rate versus placebo 6Reference 6Bartels EM et al et al. · 2015Meta-analysisEfficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials — meta-analysisView study →. The most clinically important concern is not toxicity but interaction: ginger’s pungent constituents inhibit thromboxane synthesis and platelet aggregation, and it is repeatedly named among herbs that can potentiate warfarin and increase bleeding risk, with case reports of bleeding events on concurrent use 27,28,29Reference 27Tan CSS et al et al. · 2021Systematic reviewWarfarin and food, herbal or dietary supplement interactions: a systematic review — systematic reviewView study →Reference 28Hazra S et al et al. · 2024ReviewSafety issues of herb–warfarin interactions — reviewView study →Reference 29Hirsch GE et al et al. · 2017ReviewNatural products with antiplatelet action — reviewView study →. This warrants caution with anticoagulant and antiplatelet drugs (warfarin, DOACs, aspirin, clopidogrel) and in the perioperative period — stop ginger supplements before elective surgery — and it argues against the “None noted” contraindications older versions of this page carried. A plausible additive effect with glucose- and blood-pressure-lowering drugs follows from the metabolic trials but has not been directly tested 12,15Reference 12Ebrahimzadeh A et al et al. · 2022Meta-analysisThe effect of ginger supplementation on metabolic profiles in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials — meta-analysisView study →Reference 15Hasani H et al et al. · 2019Meta-analysisDoes ginger supplementation lower blood pressure? A systematic review and meta-analysis of clinical trials — meta-analysisView study →. High intake may aggravate reflux or peptic-ulcer symptoms, so caution is advised where peptic ulceration, gastro-oesophageal reflux or other gastric disease is present 36Reference 36Bone · 2003A Clinical Guide to Blending Liquid Herbs: Herbal Formulations for the Individual Patient, and ginger is traditionally avoided where gallstones are present. Essence of ginger is also prone to adulteration — buy from a reputable supplier 37Reference 37Grieve · 1931Ginger — A Modern Herbal. http://www.botanical.com/botanical/mgmh/g/ginger13.htmlView study →.

No dedicated human pharmacokinetic (CYP450) drug-interaction trial was identified; the anticoagulant interaction is pharmacodynamic (antiplatelet activity), not a named CYP effect. The good tolerability seen in trials comes from courses of up to about 12 weeks and should not be over-read as evidence of safety at high doses indefinitely.

Pregnancy & lactation

Commonly used in pregnancy. Ginger’s single best-evidenced use is the nausea and vomiting of early pregnancy, and two meta-analyses found no increase in miscarriage or adverse fetal outcomes at therapeutic doses 1,2Reference 1Viljoen E et al et al. · 2014Meta-analysisA systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting — meta-analysisView study →Reference 2Thomson M et al et al. · 2014Meta-analysisEffects of ginger for nausea and vomiting in early pregnancy: a meta-analysis — meta-analysisView study →. Traditional and pharmacopoeial sources nonetheless advise keeping dried-ginger intake modest (commonly cited as ≤2 g/day) 36Reference 36Bone · 2003A Clinical Guide to Blending Liquid Herbs: Herbal Formulations for the Individual Patient, so the sidebar’s “no adverse reactions expected” overstates the certainty. Lactation has not been specifically studied — absence of reports is not evidence of safety.

References

  1. Viljoen E et al. (2014). A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting — meta-analysis. Nutrition Journal. https://pubmed.ncbi.nlm.nih.gov/24642205/
  2. Thomson M et al. (2014). Effects of ginger for nausea and vomiting in early pregnancy: a meta-analysis — meta-analysis. Journal of the American Board of Family Medicine. https://pubmed.ncbi.nlm.nih.gov/24390893/
  3. Matthews A et al. (2015). Interventions for nausea and vomiting in early pregnancy — systematic review (Cochrane). Cochrane Database of Systematic Reviews. https://pubmed.ncbi.nlm.nih.gov/26348534/
  4. Moshfeghinia R et al. (2024). Ginger for pain management in primary dysmenorrhea: a systematic review and meta-analysis — meta-analysis. Journal of Integrative and Complementary Medicine. https://pubmed.ncbi.nlm.nih.gov/38770631/
  5. Daily JW et al. (2015). Efficacy of ginger for alleviating the symptoms of primary dysmenorrhea: a systematic review and meta-analysis of randomized clinical trials — meta-analysis. Pain Medicine. https://pubmed.ncbi.nlm.nih.gov/26177393/
  6. Bartels EM et al. (2015). Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials — meta-analysis. Osteoarthritis and Cartilage. https://pubmed.ncbi.nlm.nih.gov/25300574/
  7. Altman RD et al. (2001). Effects of a ginger extract on knee pain in patients with osteoarthritis — randomized controlled trial. Arthritis and Rheumatism. https://pubmed.ncbi.nlm.nih.gov/11710709/
  8. Araya-Quintanilla F et al. (2020). Effectiveness of ginger on pain and function in knee osteoarthritis: a PRISMA systematic review and meta-analysis — meta-analysis. Pain Physician. https://pubmed.ncbi.nlm.nih.gov/32214292/
  9. Rjabi S et al. (2025). Antioxidant and anti-inflammatory effects of ginger supplementation in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomised controlled trials — meta-analysis. Inflammopharmacology. https://pubmed.ncbi.nlm.nih.gov/41123858/
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