Compound Monograph
Baicalein
Baicalein is a flavone from Chinese skullcap, studied for anxiolytic and anti-inflammatory activity.
Classification
Baicalein is a flavone (flavonoid), part of the phenolics class. Antioxidant compounds built around one or more phenol rings — the flavonoids, tannins, phenolic acids, coumarins, and pigments behind much of a plant's protective chemistry.
Where Does It Come From? (3)
Baicalein is a naturally occurring flavone (flavonoid), found in Chinese skullcap, Skullcap and 1 other source. It is well tolerated orally (low toxicity).
Research & Evidence
Baicalein is a flavone and one of the principal active flavonoids of Chinese skullcap (Scutellaria baicalensis), where it occurs together with its glycoside baicalin. It is among the constituents associated with skullcap’s traditional calming use and has been studied in the laboratory for anxiolytic, anti-inflammatory and antioxidant activity, including interactions with GABA-related signalling.
Toxicity & Safety
Baicalein is a dietary-type flavonoid from a long-used medicinal herb and is generally regarded as low in toxicity at the levels supplied by normal use. As with other flavonoids that may influence calming pathways, the sensible caution is the potential for additive effects when combined with sedatives; concentrated supplements are a separate matter from ordinary herbal use.