Compound Monograph
Nuciferine
Nuciferine is an aporphine alkaloid from lotus and blue lotus, studied for sedative and dopamine-related activity.
Classification
Nuciferine is an aporphine alkaloid, part of the alkaloids class. Nitrogen-containing, often bitter and physiologically potent compounds — the group behind many of the strongest plant medicines and poisons.
Where Does It Come From? (3)
Nuciferine is a naturally occurring aporphine alkaloid, found in Blue lotus, Sacred lotus and 1 other source. It is flagged as moderately toxic.
Research & Evidence
Nuciferine is an aporphine alkaloid found in the leaves and flowers of sacred lotus (Nelumbo nucifera) and in blue lotus (Nymphaea species). It has been studied in laboratory and animal models for sedative, calming and antipsychotic-like properties, with reported interactions at dopamine and serotonin receptors. It is often cited as a contributor to the relaxing reputation of lotus preparations, although controlled human data are sparse.
Toxicity & Safety
The isolated alkaloid has not been thoroughly characterised for human safety. Reported effects are generally mild and sedating, but interactions with other centrally acting drugs are plausible given its receptor activity.