Compound Monograph
Scoparone
Scoparone is a naturally occurring dimethoxycoumarin found in several plants, studied chiefly for anti-inflammatory and vascular effects.
Classification
Scoparone is a coumarin, part of the phenolics class. Antioxidant compounds built around one or more phenol rings — the flavonoids, tannins, phenolic acids, coumarins, and pigments behind much of a plant's protective chemistry.
Where Does It Come From? (4)
Scoparone is a naturally occurring coumarin, found in Broom, Mugwort and 2 other sources. It is well tolerated orally (low toxicity).
Research & Evidence
Scoparone is a simple coumarin (6,7-dimethoxycoumarin) reported from broom and a number of other plants, including Artemisia species. It has been examined in laboratory and animal studies for anti-inflammatory, vasorelaxant and lipid-lowering activity, and it is one of the components historically associated with the traditional use of certain herbs in liver and cardiovascular complaints. Most of this work remains preclinical.
Toxicity & Safety
Scoparone has not been associated with notable toxicity at the levels found in plants, but its safety in humans has not been formally characterised. As with other coumarins, isolated high-dose exposure has not been well studied.