Compound Monograph
5-MeO-DMT
5-MeO-DMT is a fast-acting psychedelic tryptamine found in several plants and in the secretions of the Sonoran Desert toad.
Classification
5-MeO-DMT is a tryptamine alkaloid, part of the alkaloids class. Nitrogen-containing, often bitter and physiologically potent compounds — the group behind many of the strongest plant medicines and poisons.
Where Does It Come From? (6)
5-MeO-DMT is a naturally occurring (and made in the body) tryptamine alkaloid, found in Sonoran Desert toad, Yopo, Virola and 3 other sources. It is flagged as moderately toxic and psychedelic.
Research & Evidence
5-MeO-DMT is a potent, short-acting psychedelic tryptamine that occurs in a number of plants used in traditional snuffs and brews, and famously in the venom of the Sonoran Desert toad. It acts on serotonin receptors, with notable activity at the 5-HT1A and 5-HT2A subtypes, and produces an intense but brief altered state, typically lasting on the order of half an hour when vaporised. Contemporary research has examined its subjective effects and its possible role in mental-health contexts, generally in supervised settings.
Toxicity & Safety
The experience can be overwhelming in intensity and is associated with risks including profound disorientation, loss of physical control, and in some cases adverse cardiovascular or psychological reactions. It is particularly hazardous when combined with MAO inhibitors or other serotonergic drugs, and is generally contraindicated for people with a personal or family history of psychosis. It is a Schedule I substance in the United States.
Dosage
Naturalistic reports and research describe vaporised doses of roughly 6–12 mg. These figures describe doses studied in research and are not a recommendation.