Compound Monograph
Isovitexin
Isovitexin is a C-glycosylated flavone (apigenin 6-C-glucoside) found in passionflower and many other plants.
Classification
Isovitexin is a flavonoid (c-glycosyl flavone), part of the phenolics class. Antioxidant compounds built around one or more phenol rings — the flavonoids, tannins, phenolic acids, coumarins, and pigments behind much of a plant's protective chemistry.
Where Does It Come From? (4)
Isovitexin is a naturally occurring flavonoid (c-glycosyl flavone), found in Passionflower, Various grains and legumes and 2 other sources. It is well tolerated orally (low toxicity).
Research & Evidence
Isovitexin is a C-glycosylated flavone — the 6-C-glucoside of apigenin and an isomer of vitexin — that occurs in passionflower and a wide range of other plants and foods. It is among the flavonoids commonly cited in connection with passionflower’s traditional calming use, although the plant’s overall effects cannot be attributed to any single constituent. Laboratory studies have examined isovitexin for antioxidant and anti-inflammatory activity.
Toxicity & Safety
As a widely distributed dietary flavone glycoside, isovitexin is generally regarded as low in toxicity at the levels encountered in foods and herbal preparations. Its isolated profile has not been characterised in detail.