Compound Monograph
N,N-DMT
N,N-DMT is a powerful, short-acting psychedelic tryptamine found across many plants and also present endogenously in mammals.
Classification
N,N-DMT is a tryptamine alkaloid, part of the alkaloids class. Nitrogen-containing, often bitter and physiologically potent compounds — the group behind many of the strongest plant medicines and poisons.
Where Does It Come From? (8)
N,N-DMT is a naturally occurring (and made in the body) tryptamine alkaloid, found in Chacruna, Jurema, Yopo and 5 other sources. It is well tolerated orally (low toxicity) and psychedelic.
Research & Evidence
N,N-Dimethyltryptamine (DMT) is a classical psychedelic tryptamine and a partial agonist at serotonin 5-HT2A receptors. It occurs in a remarkable number of plants and is the key visionary component of ayahuasca, where a monoamine oxidase inhibitor allows it to be active orally; vaporised or injected, it produces an intense but very brief experience. DMT is also produced endogenously in trace amounts in mammals, although its physiological role remains debated. Modern research has examined it for its acute psychological effects and potential therapeutic applications.
Toxicity & Safety
Physiological toxicity appears low, but the psychological intensity is considerable and can include overwhelming fear or disorientation. As a serotonergic agent it is contraindicated with MAO inhibitors and other serotonergic drugs outside controlled settings, and it carries the general risk of destabilising vulnerable individuals. It is a Schedule I substance in the United States.
Dosage
Research describes a vaporised range of roughly 20–40 mg producing a short, intense effect lasting minutes. These figures describe doses studied in research and are not a recommendation.