Compound Monograph
Serotonin
Serotonin is a monoamine neurotransmitter central to mood, sleep and gut function, also present in some plants.
Classification
Serotonin is a monoamine (indoleamine) neurotransmitter, part of the alkaloids class. Nitrogen-containing, often bitter and physiologically potent compounds — the group behind many of the strongest plant medicines and poisons.
Where Does It Come From? (6)
Serotonin is a naturally occurring (and made in the body) monoamine (indoleamine) neurotransmitter, found in Stinging nettle, Velvet bean, Walnut and 3 other sources. It is well tolerated orally (low toxicity).
Research & Evidence
Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter synthesised in the body from the amino acid tryptophan. It plays a wide-ranging role in mood, sleep, appetite, and gastrointestinal function; in fact, the large majority of the body’s serotonin is found in the gut. It is the endogenous ligand whose signalling many antidepressants and psychedelics indirectly modulate. Serotonin also occurs naturally in a number of plants, including stinging nettle and velvet bean, though dietary serotonin does not readily cross the blood-brain barrier.
Toxicity & Safety
Serotonin produced in the body is well tolerated, but excessive serotonergic activity from drugs can cause serotonin syndrome, a potentially serious condition. This is a concern with combinations of serotonergic medications rather than with serotonin from food.