Compound Monograph
Chamazulene
Chamazulene is a deep-blue sesquiterpene formed during the distillation of chamomile and yarrow oils.
Classification
Chamazulene is a sesquiterpene, part of the terpenoids class. The largest class of plant compounds, built from five-carbon isoprene units — the essential-oil aromatics, resins, bitter principles, saponins, and plant sterols.
Where Does It Come From? (5)
Chamazulene is a naturally occurring sesquiterpene, found in Chamomile, Yarrow, Cornflower and 2 other sources. It is well tolerated orally (low toxicity).
Research & Evidence
Chamazulene is an aromatic sesquiterpene responsible for the characteristic deep blue colour of chamomile and yarrow essential oils. It is not present in the fresh plant but is formed from the precursor matricin during steam distillation. It has long been associated with the traditional anti-inflammatory and soothing reputation of chamomile, and laboratory studies report antioxidant and anti-inflammatory activity.
Toxicity & Safety
Chamazulene occurs in chamomile and yarrow preparations that have a long history of traditional use and is not regarded as notably toxic. Detailed isolated-compound safety data are limited; cautions relating to chamomile (such as allergy in people sensitive to the daisy family) belong to the whole herb rather than to chamazulene specifically.