Compound Monograph
Hesperidin
A flavonoid glycoside abundant in citrus peel, studied for its effects on blood vessels and as a source of the aglycone hesperetin.
Classification
Hesperidin is a flavonoid (flavanone glycoside), part of the phenolics class. Antioxidant compounds built around one or more phenol rings — the flavonoids, tannins, phenolic acids, coumarins, and pigments behind much of a plant's protective chemistry.
Where Does It Come From? (6)
Hesperidin is a naturally occurring flavonoid (flavanone glycoside), found in Citrus fruits, especially peel and pith, Mint, Yerba santa and 3 other sources. It is well tolerated orally (low toxicity).
Research & Evidence
Hesperidin is a flavanone glycoside that is abundant in citrus fruits, particularly the peel and pith, where its aglycone is hesperetin. It is one of the citrus “bioflavonoids” and is studied in relation to capillary and venous function, with citrus flavonoid preparations used in some countries for venous insufficiency and related conditions. It also shows antioxidant and anti-inflammatory activity in laboratory work.
Toxicity & Safety
As a normal constituent of citrus and a common dietary flavonoid, hesperidin is well tolerated. It is widely available as a supplement, and reported adverse effects at usual intakes are minor.