Compound Monograph

Isorhamnetin

Isorhamnetin is a dietary flavonol, the 3'-methyl ether of quercetin, found in many plants and foods.

Work in progress

Classification

Isorhamnetin is a flavonoid (flavonol), part of the phenolics class. Antioxidant compounds built around one or more phenol rings — the flavonoids, tannins, phenolic acids, coumarins, and pigments behind much of a plant's protective chemistry.

Phenolics Flavonoids

Where Does It Come From? (8)

Isorhamnetin is a naturally occurring flavonoid (flavonol), found in Ginkgo, Calendula, African dream herb and 5 other sources. It is well tolerated orally (low toxicity).

African Dream Herb Entada rheedii Bay Bean Canavalia rosea Calendula Calendula officinalis Ginkgo Goldenrod Solidago virgaurea Sea buckthorn Stinging Nettle Urtica dioica Wormwood Artemisia absinthium

Research & Evidence

Isorhamnetin is a naturally occurring flavonol — the 3’-O-methylated derivative of quercetin — that is widespread in the plant kingdom and is a normal part of many human diets. It is found in onions, pears, ginkgo, sea buckthorn and numerous medicinal herbs, often as glycosides. Like other dietary flavonols it has been studied extensively in the laboratory for antioxidant and anti-inflammatory activities; firm conclusions about benefits in humans from isorhamnetin specifically are limited.

Toxicity & Safety

As a common dietary flavonol, isorhamnetin is regarded as low in toxicity at the levels found in foods. Concentrated supplemental exposures have not been characterised in the same detail.